Table 1.
Clinical Characteristics of Subjects Analyzed
| Variable | All (137 subjects) | Microbiome and Untargeted Metabolomics (87 subjects) | Microbiome and Targeted Metabolomics (126 subjects) | P Value |
|---|---|---|---|---|
| Age, yrs | 61.2 (8.8) | 61.3 (8.5) | 61 (8.9) | 0.85 |
| Sex, % male | 56.2 | 50.6 | 57.1 | 0.40 |
| Caucasian, % | 69.3 | 78.2 | 68.3 | 0.12 |
| Current smoker, % | 43.2 | 34.1 | 45.5 | 0.12 |
| Pack-years* | 38.2 (20) | 37.8 (15.6) | 38.1 (30.2) | 0.57 |
| Mild to moderate COPD, % | 43.8 | 41.4 | 40.5 | 1.00 |
| FEV1/FVC post-BD | 0.69 (0.12) | 0.70 (0.11) | 0.69 (0.12) | 0.48 |
| FEV1, % predicted | 89.5 (18.5) | 92.7 (17.5) | 89.8 (18.6) | 0.26 |
| FVC, % predicted | 100 (13.7) | 102 (14) | 100 (13.7) | 0.49 |
| FEF25–75, L/s | 2.00 (1.2) | 2.1 (1.2) | 2.0 (1.2) | 0.62 |
| FVC BDR, % change* | 1.9 (7.4) | 1.8 (6.9) | 1.7 (7.4) | 0.93 |
| FEV1 BDR, % change | 8.4 (7.8) | 8.49 (7.3) | 8.18 (7.9) | 0.78 |
| CAT score* | 9 (12) | 10 (12) | 9 (12) | 0.82 |
| BAL neutrophil, %*† | 1.2 (2.1) | 1.1 (1.9) | 1.2 (1.9) | 0.82 |
Definition of abbreviations: BD = bronchoscopy; BDR = bronchodilator response; CAT = COPD Assessment Test; COPD = chronic obstructive pulmonary disease; FEF25–75 = maximum midexpiratory flow.
For each row, data are either percentages with P values from Fisher’s exact tests between the two groups/frameworks, means (and SD) with P values from t tests, or median (and interquartile range) with P values from Wilcoxon rank-sum tests (*).
†
Data available for N = 86, 59, and 77, respectively.