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[Preprint]. 2024 Sep 9:2024.09.04.611294. [Version 1] doi: 10.1101/2024.09.04.611294

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Fig 7: — All sequences are used with the same resolution, echo spacing, and acceleration parameters.

A) This panel shows the CMRR multiband sequence with these protocols, where off-resonance effects and Fuzzy Ripple artifacts are clearly visible.

B) This panel displays the MGH simultaneous multi-slice sequence with the option of dual polarity GRAPPA. Whileoff-resonance effects are mitigated, Fuzzy Ripple artifacts, though reduced, remain visible.

C) This panel illustrates the same protocols using 3D-EPI. Due to its different Mz steady-state behavior, 3D-EPIinherently has a higher signal-to-noise ratio (SNR). Additionally, off-resonance effects are less noticeable, as they are smeared and partially averaged out. However, 3D-EPI still suffers from Fuzzy Ripples.

D) This panel depicts 3D-EPI with dual polarity averaging. It is visible that Fuzzy Ripples are effectively mitigated.

Acquisition parameters of data presented here are mentioned in methods section 3.6. Supplementary Figure S4 presents a reproduction of the results shown here.