Fig. 8: Examples of high resolution protocols pushing the limits of conventional protocols.

The individual panels illustrate that achieving high spatial resolution, rapid sampling (through acceleration), and imaging of lower brain areas is challenged by Fuzzy Ripples (as demonstrated in Figure 1). However, dual polarity averaging can mitigate these challenges, enabling the extension beyond the current limitations of conventional layer-fMRI protocols.

A) 3T Prisma, 3D-EPI with GRAPPA 3, 15-minute movie-watching paradigm, resolution of 0.53 mm. Acquisition parameters of the data shown here are described in methods section 3.2.

B) 7T Terra, 3D-EPI, GRAPPA 3, three times 14 min checkerboard, resolution 0.82mm, TR_vol=0.98s for 14 slices.

C) 7T Terra, 3D-EPI, GRAPPA 3, three averages of a 12-minute finger-tapping experiment, resolution of 0.82 mm. Acquisition parameters of the data shown here are described in methods section 3.7.