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[Preprint]. 2024 Sep 14:2024.09.10.612314. [Version 1] doi: 10.1101/2024.09.10.612314

Table 1. Nominal rate of empirical type 1 error rates for SCAMPI.

The empirical type I error rates for SCAMPI at nominal rates α of 10−2 and 10−3 in 100,000 simulations with 300,000 observations. The result is presented across a range of conditions including varying Minor Allele Frequencies (MAF), numbers of phenotypes J, and covariance of the phenotypes Σ when γ is simulated from a uniform distribution between 0 and 0.3. The value presented in the ‘LEQ 0.01’ and ‘LEQ 0.001’ columns reflect the pre-specified nominal error rates.

N MAF J LEQ 0.01 LEQ 0.001
3.00E+05 0.05 0.01 2 9.56E-03 1.01E-03
4 1.00E-02 1.18E-03
8 1.05E-02 1.13E-03
3.00E+05 0.05 0.25 2 9.96E-03 1.09E-03
4 1.09E-02 9.30E-04
8 1.12E-02 1.01E-03
3.00E+05 0.05 0.5 2 1.05E-02 1.16E-03
4 1.16E-02 1.02E-03
8 1.26E-02 1.23E-03
3.00E+05 0.25 0.01 2 9.51E-03 1.17E-03
4 1.03E-02 1.13E-03
8 1.00E-02 1.14E-03
3.00E+05 0.25 0.25 2 1.01E-02 1.12E-03
4 1.09E-02 1.06E-03
8 1.09E-02 9.40E-04
3.00E+05 0.25 0.5 2 1.03E-02 9.80E-04
4 1.09E-02 1.03E-03
8 1.28E-02 1.09E-03