Table 2 |.

Inhibition kinetics model fitting parameters

Inhibitor	Kinetic Model	KT urate (µM) 1	KI (µM) 1	Vmax (pmol min−1 mg−1)1	Sy.x 2
BBR	Competitive	26.08 [11.29 –48.59]	0.00213 [0.001 – 0.0042]	1591 [1355 – 1846]	306.7
	Non-Competitive	32.4 [20.7 – 47.9]	0.033 [0.025 – 0.045]	1700 [1530 – 1881]	231.0
LESU	Competitive	162.8 [126.4 – 210.1]	0.348 [0.275 – 0.439]	3625 [3335 – 3955]	196.3
	Non-Competitive	175.1 [148.8 – 206.5]	1.63 [1.46 – 1.82]	3725 [3522 – 3947]	137.2
TD-3	Competitive	82.19 [59.19 – 113.0]	0.079 [0.057 – 0.111]	2259 [2071 – 2472]	208.0
	Non-Competitive	115.3 [99.21 – 130.4]	0.44 [0.38 – 0.50]	2515 [2393 – 2644]	122.1

¹Fit value with 95% confidence interval [lower value – upper value].

²Model fit quality as reported by the standard deviation of the residuals, where $Sy.x=\sqrt{\frac{\sum \left(residua{l}^2\right)}{n-K}}$ and $n$ is the number of data points (18) and $K$ is the number of fitting parameters (3). When comparing two models, a lower value denotes a better fit. For all inhibitors tested, non-competitive models yield superior fits.