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[Preprint]. 2024 Sep 12:rs.3.rs-5065904. [Version 1] doi: 10.21203/rs.3.rs-5065904/v1

Figure 1. BMPR2i increases TCA cycle intermediates and mitochondrial respiration.

Figure 1

(A) A549 and H1299 lung cancer cell lines were treated with JL189 2.5 mM for 24 hr and then examined for (A) metabolomics done by liquid chromatography-mass spectrometry (LC-MS), (B)Metabolomics were performed comparing TCA cycle intermediates of A549 WT and A549 BMPR2 KO cells (C) Mitochondrial respiration was determined by an Agilent Seahorse analyzer on A549 and H1299 cells treated with JL189 2.5 mM for 24 hr. (D) Comparison of mitochondrial respiration between A549WT and A549 BMPR2 KO cells. The studies were performed 3–4 times