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[Preprint]. 2024 Sep 12:rs.3.rs-5065904. [Version 1] doi: 10.21203/rs.3.rs-5065904/v1

Figure 9. JL189 enhances mitochondrial bioenergetics and synergistically decreases the growth of tumor xenografts when combined with ABT-263.

Figure 9

(A) H1299 cells (2 million) were injected subcutaneously into the flanks of Balbc nude mice. After 12 days, the mice were then treated with vehicle, JL189 30 mg/kg twice daily intraperitoneally (IP), ABT-263 (Navitoclax) 12 mg/kg IP once daily, alone or in combination for 3 weeks. There were 6 mice per group. (A) Tumor volume was measured twice weekly (L x W). (B) Tumor weights were determined on day 23. (C) Photograph of the tumors. (D) Western blot analysis of tumors treated with control, JL189, ABT-263, or JL189 + ABT-263 for 3 weeks. (E) Expression was normalized to that of actin of the 6 tumors in each group.