Table 1:
Participant characteristics from the SPIROMICS and COPDGene cohorts at baseline.
| SPIROMICS | COPDGene | P Value | |
|---|---|---|---|
|
| |||
| (n = 1458) | (n = 458) | ||
|
| |||
| Age, years | 62.86 (9.13) | 63.30 (8.52) | 0.6 |
| Race | < 0.001 | ||
| White | 1,138 (78%) | 454 (99%) | |
| Non-White | 320 (22%) | 4 (0.9%) | |
| Sex | 0.008 | ||
| Male | 788 (54%) | 215 (47%) | |
| Female | 670 (46%) | 243 (53%) | |
| BMI, kg / m2 | 28.08 (5.18) | 29.93 (6.16) | < 0.001 |
| Smoking status | < 0.001 | ||
| Former or never smokers | 870 (60%) | 328 (72%) | |
| Current smokers | 588 (40%) | 130 (28%) | |
| Smoking pack years | 46.62 (28.11) | 39.42 (23.77) | < 0.001 |
| Postbronchodilator FEV1, L | 2.29 (0.87) | 2.50 (0.75) | < 0.001 |
| FEV1 / FVC ratio | 0.64 (0.15) | 0.71 (0.12) | < 0.001 |
| GOLD stage | < 0.001 | ||
| 0 | 579 (40%) | 240 (52%) | |
| 1 | 165 (11%) | 44 (9.6%) | |
| 2 | 468 (32%) | 78 (17%) | |
| 3 | 164 (11%) | 25 (5.5%) | |
| 4 | 33 (2.3%) | 1 (0.2%) | |
| Never smokers | 49 (3.4%) | 18 (3.9%) | |
| PRISm | NA | 52 (11%) | |
| Total SGRQ score | 30.18 (20.48) | 12.48 (15.26) | < 0.001 |
| 6MWD, ft | 1,342.01 (361.23) | 1,599.13 (336.83) | < 0.001 |
| mMRC dyspnea scale | 0.95 (0.95) | 0.64 (1.05) | < 0.001 |
| fSADPRM, % | 13.35 (12.21) | 10.13 (9.46) | < 0.001 |
| fSADTLC, % | 12.98 (13.25) | 9.55 (10.99) | 0.002 |
| CT emphysema (LAA < −950 HU), % | 6.59 (9.07) | 3.84 (5.88) | < 0.001 |
Data reported as mean (SD) or n (%). SPIROMICS = SubPopulations and InteRmediate Outcome Measure In COPD; COPDGene = Genetic Epidemiology of CoPD; BMI = body-mass index (kg / m2); FEV1 = forced expiratory volume in 1 second; FVC = forced vital capacity; GOLD = Global Initiative for Obstructive Lung Disease; PRISm = preserved ratio impaired spirometry; SGRQ = St. George’s Respiratory Questionnaire; 6MWD = six minute walk distance (ft); mMRC = modified Medical Research Council; fSAD = functional small airways disease; TLC = total lung capacity; PRM = parametric response mapping; CT = computed tomography; LAA = low-attenuation areas (%). P values were generated using Wilcoxon’s rank sum test or Pearson’s Chi-squared test.