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[Preprint]. 2024 Sep 11:2024.09.10.24313079. [Version 1] doi: 10.1101/2024.09.10.24313079

Table 3:

Multivariable associations of baseline fSADTLC with lung function, symptom burden, and exercise capacity in the COPDGene cohort (Estimate, 95% CI, P Value).

fSADTLC P Value fSADPRM P Value

Postbronchodilator FEV1, L −0.032 (−0.038, −0.027) P < 0.001 −0.032 (−0.038, −0.026) P < 0.001
Postbronchodilator FEV1 / FVC −0.007 (−0.008, −0.007) P < 0.001 −0.007 (−0.008, −0.006) P < 0.001
SGRQ 0.190 (0.030, 0.350) 0.02 0.131 (−0.043, 0.304) 0.14
6MWD, ft −2.211 (−5.755, 1.332) 0.22 −2.505 (−6.332, 1.321) 0.20
mMRC Dyspnea Scale 0.004 (−0.023, 0.03) 0.76 −0.008 (−0.037, 0.021) 0.60

CI = confidence interval; fSAD = functional small airways disease; TLC = total lung capacity; FEV1 = forced expiratory volume in 1 second; FVC = forced vital capacity; SGRQ = St. George’s Respiratory Questionnaire; 6MWD = six-minute walk distance; mMRC = modified Medical Research Council. Multivariable models were adjusted for age, sex, race, smoking status, smoking pack years, body-mass index (BMI), baseline postbronchodilator FEV1, and percent emphysema define as percent LAA < −950 Hounsfield units (HU).