Table 3.

Baseline staging of NSD participants in the PPMI, PASADENA, and SPARK studies

					PPMI (cohort at enrollment)							PASADENA	SPARK
Variable	Sporadic PD (N = 507)	LRRK2PD (N = 87)	GBA PD (N = 56)	SNCA PD (N = 9)	PRKN PD (N = 2)	RBD (N = 61)	Hyposmia (N = 40)	LRRK2 NMC (N = 12)	GBA NMC (N = 11)	SNCA NMC (N = 3)	HC (N = 15)	Early PD (N = 61)	Early PD (N = 110)
Stage, n (%)
0	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	3 (100%)	N/A	NA	NA
1A	0	0	0	0	0	0	0	3 (25%)	4 (36%)	0	6 (40%)	0	0
1B	0	0	0	0	0	0	0	3 (25%)	0	0	0	0	0
2A	2 (<1%)	0	0	0	0	19 (31%)	10 (25%)	4 (33%)	6 (55%)	0	8 (53%)	0	14(13%)
2B	126 (25%)	10 (11%)	7 (13%)	1 (11%)	1 (50%)	30 (49%)	25 (63%)	2 (17%)	0	0	1 (7%)	16 (26%)	28 (25%)
3	328 (65%)	53 (61%)	33 (59%)	3 (33%)	1 (50%)	5 (8%)	4 (10%)	0	1 (9%)	0	0	40 (66%)	61 (55%)
4	50 (10%)	22 (25%)	15 (27%)	4 (44%)	0	6 (10%)	1 (3%)	0	0	0	0	5 (8%)	7 (6%)
5	1 (<1%)	1 (1%)	1 (2%)	1 (11%)	0	1 (2%)	0	0	0	0	0	0	0
6	0	1 (1%)	0	0	0	0	0	0	0	0	0	0	0

HC= Healthy controls. NMC=non-manifesting carriers. PD=Parkinson’s disease. RBD=REM sleep behavior disorder