Table 3.

Facilitators and barriers to effectiveness overall and within each 3HP delivery strategy

3HP delivery strategy	Facilitators	Barriers
Overall	Automated weekly dosing/clinic appointment reminders - It helped me because doctor, you may forget and may not know that tomorrow, I have to return but when they remind you by calling you, you get to know and say eh! Tomorrow I am returning to the hospital. Then you prepare and come. (Female participant, Facilitated DOT)	High pill burden at the beginning using loose pills of isoniazid and rifapentine (eleven pills per weekly dose) - Oh, the number yes, it was a challenge, they were so many that after taking them you could feel like vomiting. (Female participant, Patient Choice)
	Reimbursement of travel costs - Another benefit was that we used to come with the hope that I would take my drugs from the clinic but there was something else that I would carry home. That also encouraged us. Personally, it encouraged me so much. (Female participant, Facilitated DOT)	3HP-related side effects - After the first dose I felt sick until I decided to stop taking the medicine. (Female participant, Facilitated SAT)
	Social support - The boss (work employer) first asked me to explain to him ...... he said if that is it, okay it’s good, every Wednesday when it reaches tell me so that if you have a safari to go I can cancel and another one goes or you look for another driver you give him and he goes then you wait for your day. (Male participant, Facilitated SAT)	COVID-19 pandemic-related treatment disruptions - I stopped during the COVID-19 lockdown because the situation was tough. I had to walk to pick up the medication (from the clinic) given that there were no transportation means.... And because I was not earning, I decided to go to the village. (Female participant, Patient Choice)
Facilitated SAT	Packaging of 3HP medicines - “It’s a good one (the pill pack) that it keeps the medication safe. You know, at home, you might have people touching here and there, so once they know that that thing is for your medication, nobody will tamper with it. So, it keeps the medication safe.” (Male participant, Facilitated SAT).

3HP weekly isoniazid-rifapentine for three months, DOT directly observed therapy, SAT self-administered therapy, Patient Choice between facilitated DOT & SAT arms