Table 1.
Baseline characteristics of the study participants and initial procedures.
| TTM (n = 87) | Control (n = 54) | P value | ||
|---|---|---|---|---|
| Age (yr), mean ± SEM | 59.8 ± 1.5 | 62.5 ± 1.9 | 0.25 | |
| Male, n (%) | 70 (80.5) | 42 (77.8) | 0.70 | |
| Medical history, n (%) | Hypertension | 38 (43.7) | 22 (40.7) | 0.60 |
| Diabetes mellitus | 28 (32.2) | 17 (31.5) | 0.93 | |
| Chronic heart failure | 24 (27.6) | 15 (27.8) | 0.98 | |
| Coronary artery disease | 22 (25.3) | 12 (22.2) | 0.68 | |
| End-stage renal disease | 16 (18.4) | 10 (18.5) | 0.98 | |
| Cerebrovascular disease | 7 (8.0) | 3 (5.6) | 0.58 | |
| Chronic obstructive pulmonary disease | 2 (2.3) | 1 (1.9) | 0.86 | |
| Initial cardiac rhythm, n (%) | Shockable | 55 (63.2) | 33 (61.1) | 0.80 |
| Non-shockable | 32 (36.8) | 21 (38.9) | 0.80 | |
| Initial core body temperature (°C), mean ± SEM | 35.7 ± 0.1 | 35.6 ± 0.1 | 0.55 | |
| CPR time (min), mean ± SEM | 21.6 ± 2.3 | 23.8 ± 3.1 | 0.29 | |
| Cardiogenic shock, n (%) | 36 (41.4) | 22 (40.7) | 0.94 | |
| CHD, n (%) | Coronary angiography | 66 (75.9) | 39 (72.2) | 0.63 |
| Left main disease | 10 (11.5) | 4 (7.4) | 0.43 | |
| Triple vessel disease | 33 (37.9) | 21 (38.9) | 0.91 | |
| AMI, n (%) | Percutaneous coronary intervention | 50 (57.5) | 30 (55.6) | 0.82 |
| ST-elevation MI | 31 (35.6) | 18 (33.3) | 0.78 | |
| Non-ST-elevation MI | 19 (21.8) | 12 (22.2) | 0.96 | |
| Intra-aortic balloon pump, n (%) | 26 (29.9) | 15 (27.8) | 0.79 | |
| Extracorporeal membrane oxygenation, n (%) | 28 (32.2) | 20 (37.0) | 0.55 | |
| Blood biochemistry parameters, mean ± SEM | hs-CRP (mg/L) | 1.6 ± 0.2 | 2.2 ± 0.3 | 0.18 |
| Fasting glucose (mg/dL) | 339.5 ± 17.6 | 324.3 ± 23.8 | 0.70 | |
| Total cholesterol (mg/dL) | 158.0 ± 6.3 | 135.8 ± 6.5 | 0.08 | |
| Triglyceride (mg/dL) | 91.6 ± 5.0 | 115.9 ± 8.6 | 0.06 | |
| LDL-C (mg/dL) | 98.1 ± 5.8 | 80.0 ± 5.2 | 0.10 | |
| HDL-C (mg/dL) | 35.7 ± 1.3 | 32.2 ± 1.6 | 0.21 | |
| Albumin (g/dL) | 3.1 ± 0.1 | 2.8 ± 0.1 | 0.09 | |
| NT pro-BNP (pg/mL) | 7699.2 ± 1059.0 | 9569.1 ± 1204.4 | 0.62 | |
| LVEF (%), mean ± SEM | 36.3 ± 1.8 | 32.3 ± 2.3 | 0.17 | |
AMI = acute myocardial infarction, CHD = coronary heart disease, CPR = cardiopulmonary resuscitation, HDL-C = high-density lipoprotein cholesterol, hs-CRP = high-sensitivity C-reactive protein, LDL-C = low-density lipoprotein cholesterol, LVEF = left ventricular ejection fraction, MI = myocardial infraction, NT pro-BNP = N-terminal pro-brain natriuretic peptide, SEM = standard error of the mean, TTM = targeted temperature management.