Table 2.
Clinical biochemistry parameters and blood count during the first 24 h after resuscitation.
| After resuscitation | TTM (n = 87) | Control (n = 54) | P value | |
|---|---|---|---|---|
| Liver and kidney function markers, mean ± SEM | ||||
| AST (IU/L) | 0 h | 456.1 ± 77.8 | 255.4 ± 35.7 | .32 |
| 24 h | 977.2 ± 204.8 | 967.6 ± 208.8 | .99 | |
| 24-h difference | +114.3%, P < .001† | +278.9%, P < .001† | .16* | |
| ALT (IU/L) | 0 h | 211.8 ± 47.2 | 113.0 ± 13.4 | .41 |
| 24 h | 291.0 ± 78.2 | 140.9 ± 17.6 | .45 | |
| BUN (mg/dL) | 0 h | 35.1 ± 2.9 | 40.7 ± 3.7 | .25 |
| 24 h | 32.7 ± 2.4 | 41.4 ± 3.9 | .05 | |
| Creatinine (mg/dL) | 0 h | 2.2 ± 0.2 | 2.5 ± 0.3 | .40 |
| 24 h | 2.2 ± 0.2 | 2.4 ± 0.3 | .60 | |
| Muscle and cardiac markers, mean ± SEM | ||||
| CK (IU/L) | 0 h | 434.4 ± 50.5 | 350.9 ± 56.4 | .29 |
| 24 h | 3923.4 ± 635.8 | 3732.9 ± 735.7 | .86 | |
| 24-h difference | +803.2%, P < .001† | +963.8%, P < .001† | .92* | |
| CK-MB (ng/mL) | 0 h | 28.9 ± 4.8 | 25.7 ± 4.6 | .66 |
| 24 h | 230.2 ± 37.3 | 197.1 ± 43.9 | .57 | |
| 24-h difference | +696.5%, P < .001† | +666.9%, P < .001† | .61* | |
| Troponin-I (ng/mL) | 0 h | 1.5 ± 0.4 | 1.8 ± 0.6 | .67 |
| 24 h | 30.7 ± 3.6 | 27.7 ± 4.0 | .59 | |
| 24-h difference | +1946.7%, P < .001† | +1438.9%, P < .001† | .65* | |
| Blood count, mean ± SEM | ||||
| WBC (K/μL) | 0 h | 13.9 ± 0.6 | 13.8 ± 0.5 | .95 |
| 24 h | 14.9 ± 0.8 | 13.2 ± 0.5 | .11 | |
| Neutrophils (K/μL) | 0 h | 8.4 ± 0.5 | 8.5 ± 0.3 | .90 |
| 24 h | 12.7 ± 0.7 | 11.2 ± 0.5 | .11 | |
| 24-h difference | +51.2%, P < .001† | +31.8%, P < .001† | .12* | |
| Hemoglobin (g/dL) | 0 h | 12.5 ± 0.3 | 12.1 ± 0.3 | .36 |
| 24 h | 11.6 ± 0.3 | 10.8 ± 0.3 | .07 | |
| 24-h difference | −7.2%, P < .001† | −10.7%, P < .001† | .31* | |
| Platelets (K/μL) | 0 h | 186.5 ± 7.9 | 166.2 ± 10.9 | .13 |
| 24 h | 152.1 ± 7.3 | 129.5 ± 9.1 | .06 | |
| 24-h difference | −18.4%, P < .001† | −22.1%, P < .001† | .85† | |
24-h difference = (level at 24 hours after resuscitation—level at resuscitation)/level at resuscitation, P value = differences between the 2 groups using Student t test.
ALT = alanine aminotransferase, AST = aspartate aminotransferase, BUN = blood urea nitrogen, CK = creatine kinase, CK-MB = creatine kinase-MB isoenzyme, MANOVA = multivariate analysis of variance, SEM = standard error of the mean, TTM = targeted temperature management, WBC = white blood cells.
*
P value = interaction effect, differences between the 2 groups, and over time using the MANOVA model.
†
P value = time differences using the paired t test.