Fig. 6. 6b significantly suppressed HCC1806 xenograft and UM1 patient-derived xenograft tumor growth in nude mice.

A Gross morphology of HCC1806 xenografts tumor after intraperitoneal injection with 6b (5 mg or 10 mg kg⁻¹). DMSO is a negative control for 24 days (n = 6). B 6b significantly inhibited tumor volumes. C 6b significantly decreased tumor weights. D 6b did not significantly change mouse body weights. E. The KLF5, BRD4, and Ki-67 levels were quantified by Image J after staining with specific antibodies in paraffin-embedded tissues, scale bar equals 50 μM. F Gross morphology of UM1 xenografts tumor after mammary fat pad implantation with 6b (5 mg or 10 mg kg⁻¹). DMSO serves as a negative control (n = 6). G 6b significantly inhibited UM1 tumor growth. H 6b significantly decreased tumor weights I. 6b did not affect the mouse bodyweight. J The KLF5, BRD4, and Ki-67 levels were quantified by Image J after staining with specific antibodies in paraffin-embedded tissues, scale bar equals 50 μM. The data are represented as means ± SD. n ≥ 6 for mice in each group. (*p < 0.05, **p < 0.01. ***p < 0.001. t-test).