Table 5.

Infectious workup during ibrutinib therapy.

	Test
		Clinical Presentation Assessment:	Blood cell count, chemistry, C-reactive protein, and procalcitonin
Blood and urine cultures, sputum culture test
Chest CT
Serologic tests for atypical pneumonia, antigen tests for Legionella and Pneumococcal
PCR viral respiratory panel
Abdominal ultrasonography, CT scan, and MRI based on clinical suspicion
Additional Tests Based on Clinical Suspicion	Galactomannan serum antigen and 1-3-β-D-glucan
	herpetic viruses
	mycobacteria
	cryptococcus
Targeted Examinations if Initial Investigations are Inconclusive	Bronchoalveolar lavage for culture test
	Histopathological examination of tissue biopsies
	Lumbar Puncture and Central Nervous System MRI