Table 1.
Baseline characteristics
| Stroke group | Non-stroke group | p-value* | |
|---|---|---|---|
| Total cohort, n (% of all patients) | 137 (21.5) | 501 (78.5) | - |
| Male sex, n (%) | 86 (62.8) | 304 (60.7) | 0.66 |
| Age [years], median (IQR) | 76 (72; 80) | 77 (73; 82) | 0.09 |
| Body mass index [kg/m2], median (IQR) | 26.4 (24.1; 29.8) | 26.8 (24.2; 30.2) | 0.61 |
| CHA2DS2-VASc score, mean ± SD | 5.9 ± 1.3 | 4.1 ± 1.4 | < 0.001 |
| HAS-BLED score, mean ± SD | 4.6 ± 1.0 | 3.7 ± 1.1 | < 0.001 |
| Arterial hypertension, n (%) | 132 (96.4) | 461 (92.0) | 0.08 |
| Diabetes mellitus, n (%) | 53 (38.7) | 164 (32.7) | 0.19 |
| Congestive heart failure, n (%) | 33 (24.1) | 139 (27.7) | 0.39 |
| Coronary heart disease, n (%) | 58 (42.3) | 234 (46.7) | 0.36 |
| eGFR [MDRD], median (IQR) | 65.9 (41.8; 86.0) | 61.0 (41.7; 78.3) | 0.17 |
| Pattern of AF, each n (%) | |||
| • Paroxysmal | 58 (42.3) | 216 (43.1) | 0.87 |
| • Persistent | 23 (16.8) | 92 (18.4) | 0.67 |
| • Permanent | 56 (40.9) | 193 (38.5) | 0.62 |
| Prior pulmonary vein isolation, n (%) | 6 (4.4) | 11 (2.2) | 0.16 |
| Indication for LAAO, each n (%) | |||
| • Prior bleeding | 97 (70.8) | 410 (81.8) | 0.005 |
| • Contraindication to OAC | 28 (20.4) | 93 (18.6) | 0.62 |
| • Labile INR | 12 (8.8) | 42 (8.4) | 0.89 |
| • OAC incompliance | 8 (5.8) | 25 (5.0) | 0.69 |
| • Patient’s preference | 30 (21.9) | 131 (26.1) | 0.31 |
| • Other reason | 15 (10.9) | 43 (8.6) | 0.39 |
| Ejection fraction [%], median (IQR) | 60 (50; 60) | 60 (50; 60) | 0.75 |
| Ejection fraction ≤ 40%, n (%) | 14 (10.7) | 60 (12.3) | 0.61 |
| LA diameter [mm], median (IQR)** | 47 (44; 50) | 48 (44; 52) | 0.223 |
| LA area [cm2], median (IQR)** | 30 (21; 44) | 26 (20; 32) | 0.21 |
* Tested by Pearson’s chi-squared or Mann–Whitney-Wilcoxon test; bold indicates p ≤ 0.05; more than one item could occur in the same patient; **these two measurements could be documented alternatively; AF, atrial fibrillation; eGFR, estimated glomerular filtration rate; INR, international normalized ratio; IQR, interquartile range; LA(AO), left atrial (appendage occlusion); MDRD, Modification of Diet in Renal Disease [equation]; OAC, oral anticoagulation; SD, standard deviation