Table 2.
Univariable and multivariable Cox regression analyses for the prediction of CSS in the Discovery cohort
| Parameter | Univariable | Multivariable | ||
|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Age < 75 | 1.19 (0.83, 1.69) | 0.346 | ||
| ECOG performance status > 1 | 2.36 (1.47, 3.78) | < 0.001 | ||
| Pain at diagnosis | 2.25 (1.54, 3.29) | < 0.001 | ||
| PSA > 200 ng/ml | 1.90 (1.32, 2.74) | < 0.001 | ||
| Primary Gleason pattern 5 | 2.38 (1.66, 3.42) | < 0.001 | 1.93 (1.30, 2.88) | 0.001 |
| EOD ≥ 2 | 2.82 (1.93, 4.12) | < 0.001 | 1.95 (1.25, 3.05) | 0.003 |
| Hemoglobin < 13.0 g/dl | 1.70 (1.19, 2.41) | 0.003 | ||
| Lactate dehydrogenase > 250U/l | 3.37 (2.34, 4.85) | < 0.001 | 1.57 (1.01, 2.45) | 0.047 |
| Alkaline phosphatase > 300 U/l | 2.52 (1.71, 3.70) | < 0.001 | ||
| Albumin ≤ 3.7 g/dl | 3.95 (2.76, 5.66) | < 0.001 | 3.00 (2.02, 4.47) | < 0.001 |
| Lung metastasis | 0.82 (0.50, 1.34) | 0.433 | ||
| Liver metastasis | 3.45 (1.75, 6.82) | < 0.001 | 2.12 (1.00, 4.50) | 0.049 |
EOD extent of disease, GS Gleason score, LDH lactate dehydrogenase, ALB albumin