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. 2024 May 31;73(10):1599–1600. doi: 10.1136/gutjnl-2024-332577

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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High prevalence of HEV-3 RNA in PERT correlates with an increased HEV seroprevalence in a Canadian cohort of individuals suffering from cystic fibrosis. Roughly 40% of porcine-derived PERT medications sourced from Canadian suppliers exhibited detectable levels of HEV-3 RNA. The potential contamination of PERT with infectious HEV might contribute to the increased prevalence of HEV antibodies and the chronic progression of HEV infection among cystic fibrosis patients when compared with a control group showing clinical indications of viral hepatitis. Figure created with BioRender.com. HEV, hepatitis E virus; PERT, pancreatic replacement therapy.