. 2024 Apr 24;230(3):624–634. doi: 10.1093/infdis/jiae198

Table 2.

Likelihood of Recovery or Death Based on Baseline Viral Load or Inflammatory Biomarker

	Recovery			Mortality
Disease Severity: Biomarker	RRR	95% CI	P Value	HR	95% CI	P Value
Moderate/severe
Nucleocapsid, log₁₀ pg/mL	0.53	.42–.66	<.001	3.92	1.11–13.86	.034
RNA, log₁₀ copies/mL
Plasma	0.41	.33–.53	<.001	4.44	1.41–13.96	.011
Upper respiratory	0.50	.40–.64	<.001	7.80	1.70–35.82	.008
Inflammatory Biomarkers, log₁₀ pg/mL
CRP	0.83	.67–1.04	.106	1.79	.65–4.95	.259
IL-6	0.53	.42–.67	<.001	3.68	1.32–10.29	.013
Critical
Nucleocapsid, log₁₀ pg/mL	0.77	.58–1.03	.078	1.07	.61–1.87	.805
RNA, log₁₀ copies/mL
Plasma	0.58	.44–.78	<.001	1.53	.83–2.85	.175
Upper respiratory	0.84	.63–1.12	.239	1.12	.64–1.98	.687
Inflammatory Biomarkers, log₁₀ pg/mL
CRP	0.74	.55–1.00	.050	1.75	.93–3.29	.085
IL-6	0.39	.28–.53	<.001	3.55	1.41–8.96	.007

Cox model estimates of HR for mortality and RRR based on baseline elevation of viral load or inflammatory biomarker (dichotomized at baseline median) when adjusted for treatment arm.

Abbreviations: CRP, C-reactive protein; HR, hazard ratio; IL-6, interleukin 6; RRR, recovery rate ratio