Table 1:

Known LPA receptors and their knockout mouse phenotypes.

LPA receptor	Gene name	Other names	Knockout mouse major phenotype	References for knockout mouse
LPA1	Lpar1	vzg1, Edg2, LPA1	Impaired suckling in neonatal pups leading to ~50% perinatal death, craniofacial abnormalities	(Contos et al. 2000)
LPA2	Lpar2	Edg4, LPA2	No obvious abnormalities	(Contos et al. 2002)
LPA3	Lpar3	Edg7, LPA3	Embryo implantation defects in mothers	(Ye et al. 2005)
LPA4	Lpar4	GPR23, p2y9	Embryonic vascular defects	(Sumida et al. 2010)
LPA5	Lpar5	GPR92	No obvious abnormalities	(Lin et al. 2012)
LPA6	Lpar6	p2y5	Mouse phenotype has not been reported, but hair loss with a mutation in humans	(Pasternack et al. 2008; Nahum et al. 2011)

Gene name refers to the murine gene nomenclature.