TABLE 1.
Neutralizability of consecutive isolates obtained from cats infected with TCA FIV, as determined with a panel of immune sera
| Immune seruma | Neutralizing antibody titer with virus isolate obtained from:b
|
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cat 275 at indicated mo p.i.
|
Cat 311 at indicated mo p.i.
|
Cat 583 at indicated mo p.i.
|
|||||||||||
| 1 | 3 | 6 | 10 | 15 | 10 | 15 | 1 | 3 | 6 | 10 | 15 | 20 | |
| 2581-9 | 128 | 512 | 11 | − | − | 8 | − | 128 | 181 | 181 | >512 | 45 | − |
| 857-12 | 32 | 181 | 11 | − | − | − | − | 8 | − | 8 | NDc | 45 | 11 |
| 874-12 | 512 | 512 | 152 | 32 | − | 45 | 8 | >512 | >512 | >512 | >512 | 45 | 8 |
| 902-12 | 128 | 512 | 11 | − | − | − | − | >512 | >512 | 128 | 512 | 181 | − |
| 905-12 | 128 | 512 | 11 | − | − | − | − | − | 8 | 64 | 194 | 11 | − |
| 338-32 | 181 | 128 | 8 | − | − | 38 | − | >512 | 512 | >512 | >512 | 14 | 32 |
| 2906-32 | 512 | 181 | 13 | − | − | − | − | >512 | 512 | >512 | 181 | 11 | − |
| 3368-32 | 128 | 181 | 11 | − | − | 11 | − | 512 | >512 | 512 | 181 | 45 | 45 |
| 338-41 | 181 | >512 | 11 | − | − | − | − | >512 | >512 | >512 | 512 | 181 | 157 |
| 2906-41 | 512 | 45 | 11 | − | − | − | − | 512 | >512 | >512 | 128 | 11 | ND |
| 3368-41 | >512 | 181 | 11 | − | − | − | − | >512 | 512 | >512 | 128 | 38 | 11 |
a
The number before the dash identifies the donor cat; the number after the dash identifies the month p.i. when the serum was obtained. Cats were infected with virus FL-181 (no. 338, 2906, and 3368) or with the same virus passaged three (no. 2581) or six (no. 857, 874, 902, and 905) times in SPF cats.
b
Values shown are the geometric means of the titers obtained in two independent assays. −, no neutralizing activity detected; mean titers of <8 were not considered significant and were scored as negative.
c
ND, not done.