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. 2001 May;75(10):4584–4593. doi: 10.1128/JVI.75.10.4584-4593.2001

TABLE 4.

Summary of differential amino acids found in NR and NI sequential isolates and not found in any of the NS variants examined

Isolate (mo) Phenotype No.a Amino acid change at position:
195 196 197 228 279 359 392 397 409 410 422 468 469 471 472 481 510 557 558 559 603
Early revertants
 3524 (4) NR 1/5 K→N
 275 (6) NI 1/8 K→E
 275 (10) NR 3/11 T→P Q→R K→E
 275 (15) NR 6/13 W→S D→Q C→G S→T K→E K→E
 311 (10) NR 6/14 V→I K→E K→N G→S T→I M→L
 311 (15) NR 6/14 V→I K→E K→N G→S T→I M→L
 583 (15) NI 1/8 K→Nb
 583 (20) NI 2/9 S→P K→N
Putative long-term revertants
 338 (36) NR 4/11 R→K K→E V→I S→N
 3368 (36) NR 2/8 N→T S→N
 2906 (36) NR 7/12 K→E K→R S→N K→M L→F K→E S→N
a

Substitutions found in NR or NI variants only/total number of substitutions present in the variant. 

b

Replacement occurred in 50% of sequences.