Fig. 7.

Biological/biochemical functions of the genes commonly affected in U251 and U87 cells by i.c. growth. The genes identified by sam as being modulated by i.c. growth in SCID mice in both the glioma cells lines as compared with tissue culture and s.c. growth conditions were subjected to gostat analysis for determination of specific functions. (A) The GO pathways existing under biological processes with those overrepresented or underrepresented in the i.c. tumors indicated. (B) Pathways under cellular processes overrepresented in the i.c. tumors versus tissue culture and s.c. tumors. (C) Pathways under development overrepresented in the i.c. tumors versus tissue culture. (D) Pathways under physiological process underrepresented in the i.c. tumors versus tissue culture. The numbers of genes distributed to each pathway are listed to the right of each pathway. The statistical significance of each distribution is denoted by * for P < 0.001 and ** for P < 0.01.