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. Author manuscript; available in PMC: 2024 Sep 24.
Published in final edited form as: Nature. 2024 May 2;631(8019):87–93. doi: 10.1038/s41586-024-07474-1

Extended Data Fig. 1 |. Additional examples of pyrimidine functionalization and pyrimidine to pyridine conversion.

Extended Data Fig. 1 |

a, Additional example of pyrimidine halogenation. b, Additional examples of pyrimidine to pyridine conversion using methyl ketones. Isolated yields are shown. Vinamidinium salt formation: Tf2O (1 equiv), 4-trifluoromethylaniline (1 equiv), collidine (1 equiv), EtOAc, −78 °C to room temperature, then pyrrolidine (6 equiv), EtOH, 60 °C. aIsolated yield of vinamidinium salt from pyrimidine.