Table 3.
Lung cancer diagnosis in 810 screening participants with two consecutive MSC test results within two years.
| MSC test shift | # of participants | Median time of diagnosis from the last MSC test | LC within 1 year (%)a | RR (95% CI) | p-value | LC within 2 years (%)b | RR (95% CI) | p-value | Total LC (%) | RR (95% CI) | p-value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MSC− ≥ MSC− | 312 | 14.4 m | 11 (3.5) | Reference | 0.5591 | 19 (6.1) | Reference | 0.583 | 24 (7.7) | Reference | 0.5485 |
| MSC+ ≥ MSC− | 221 | 6.8 m | 10 (4.5) | 1.3 (0.6–3.0) | 11 (5.0) | 0.8 (0.4–1.7) | 14 (6.3) | 0.8 (0.4–1.6) | |||
| MSC− ≥ MSC+ | 122 | 3.0 m | 18 (14.8) | 4.2 (2.0–8.6) | 0.0772 | 21 (17.2) | 2.8 (1.6–5.1) | 0.0866 | 24 (19.7) | 2.5 (1.5–4.3) | 0.0943 |
| MSC+ ≥ MSC+ | 155 | 3.0 m | 36 (23.2) | 6.6 (3.4–12.6) | 40 (25.8) | 4.2 (2.5–7.1) | 44 (28.4) | 3.7 (2.3–5.8) | |||
| Total | 810 | 4.0 m | 75 | 91 | 106 |
LC, lung cancer; MSC, 24-microRNA signature classifier; RR, relative risk.
a
Lung cancer diagnosis within 1 year of last MSC test result.
b
Lung cancer diagnosis within 2 years of last MSC test result.