TABLE 1.
Ganglioside-binding specificities of SV, hPIV-1, and hPIV-3
| Ganglioside | Structurea | Binding activity withb:
|
||
|---|---|---|---|---|
| SV | hPIV-1 | hPIV-3 | ||
| GM3(NeuAc) | NeuAcα2-3Galβ1-4Glcβ1-1′Cer | + | − | − |
| Ganglio series | ||||
| GM1a | Galβ1-3GalNAcβ1-4Galβ1-4Glcβ1-1′Cer | − | − | − |
| 3 | ||||
| | | ||||
| 2αNeuAc | ||||
| GD1a | NeuAcα2-3Galβ1-3GalNAcβ1-4Galβ1-4Glcβ1-1′Cer | ++ | − | − |
| 3 | ||||
| | | ||||
| 2αNeuAc | ||||
| GD1b | Galβ1-3GalNAcβ1-4Galβ1-4Glcβ1-1′Cer | − | − | − |
| 3 | ||||
| | | ||||
| 2αNeuAcα2-8NeuAc | ||||
| GT1b | NeuAcα2-3Galβ1-3GalNAcβ1-4Galβ1-4Glcβ1-1′Cer | ++ | − | − |
| 3 | ||||
| | | ||||
| 2αNeuAcα2-8NeuAc | ||||
| GQ1b | Galβ1-3GalNAcβ1-4Galβ1-4Glcβ1-1′Cer | +++ | − | − |
| 33 | ||||
| || | ||||
| NeuAcα2-8NeuAcα2 2αNeuAcα2-8NeuAc | ||||
| Neolacto series | ||||
| NeuAcα2-3PG | NeuAcα2-3Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ1-1′Cer | +++ | ++ | ++ |
| NeuAcα2-6PG | NeuAcα2-6Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ1-1′Cer | ++ | − | ++ |
| NeuAcα2-3i | NeuAcα2-3Galβ1-4GlcNAcβ1-3Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ1-1′Cer | +++ | ++ | ++ |
| NeuAcα2-3I | NeuAcα2-3Galβ1-4GlcNAcβ1-6 | |||
| Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ1-1′Cer | +++ | +++ | +++ | |
| NeuAcα2-3Galβ1-4GlcNAcβ1-3 | ||||
| NeuAcα2-61 | Galβ1-4GlcNAcβ1-6 | |||
| Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ1-1′Cer | ++ | − | +++ | |
| NeuAcα2-6Galβ1-4GlcNAcβ1-3 | ||||
| NeuGcα2-3I | Galβ1-3Galβ1-4GlcNAcβ1-6 | |||
| Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ1-1′Cer | ++ | ++ | +++ | |
| NeuGcα2-3Galβ1-4GlcNAcβ1-3 | ||||
a
Sialic acids in the ganglioside structures are shown in bold.
b
The binding activities of SV, hPIV-1, and hPIV-3 for each ganglioside were estimated as the concentration at which 50% virus binding occurred in a solid-phase binding assay. +++, between 1 and 10 pmol; ++, between 10 and 100 pmol; +, between 100 and 1,000 pmol; −, more than 1,000 pmol.