Table 2.
Type of disease-free events in young BRCA carriers with pure ductal versus pure lobular breast cancer
| Pure ductal BC n (%) n = 3969 |
Pure lobular BC n (%) n = 135 |
P value | |
|---|---|---|---|
| Follow-up (years), median (IQR) | 7.77 (4.47-12.62) | 8.25 (4.73-14.41) | |
| No events | 2529 (63.7) | 77 (57.0) | 0.122 |
| Locoregional recurrence | 301 (7.6) | 17 (12.6) | 0.047 |
| Distant recurrence | 446 (11.2) | 18 (13.3) | 0.410 |
| Second primary malignancy | 159 (4.0) | 2 (1.5) | 0.175 |
| Ovary | 91 (2.3) | 1 (0.7) | |
| Pancreas | 9 (0.2) | 0 (0.0) | |
| Cervix | 9 (0.2) | 0 (0.0) | |
| Colorectal | 11 (0.3) | 0 (0.0) | |
| Hematology | 8 (0.2) | 0 (0.0) | |
| Skin | 18 (0.5) | 1 (0.7) | |
| Thyroid | 9 (0.2) | 0 (0.0) | |
| Endometrial | 8 (0.2) | 0 (0.0) | |
| Upper gastrointestinal tract | 5 (0.1) | 0 (0.0) | |
| Other | 30 (0.8) | 0 (0.0) | |
| Second primary breast cancer | 496 (12.5) | 18 (13.3) | 0.791 |
| Death without any disease-free survival event | 38 (1.0) | 3 (2.2) | 0.151 |
BC, breast cancer; IQR, interquartile range.