TABLE 1.
SEER Cancer Categorization
| Stage | T | N | M | Surgery | SEER Category |
|---|---|---|---|---|---|
| Stage 0a | Ta | N0 | M0 | No constraint | NMIBC |
| Stage 0is | Tis | N0 | M0 | No constraint | NMIBC |
| Stage I | T1 | N0 | M0 | No constraint | NMIBC |
| Stage II | T2a | N0 | M0 | No constraint | MIBC |
| T2b | N0 | M0 | No constraint | MIBC | |
| Stage IIIA | T3a | N0 | M0 | No constraint | MIBC |
| T3b | N0 | M0 | Cancer-directed surgery or radiation | MIBC | |
| T4a | N0 | M0 | Cancer-directed surgery or radiation | MIBC | |
| T1-T4a | N1 | M0 | Cancer-directed surgery or radiation | MIBC | |
| Stage IIIB | T1-T4a | N2,N3 | M0 | Cancer-directed surgery or radiation | MIBC |
| Stage IVA | T4b | Any N | M0 | Cancer-directed surgery or radiation | MIBC |
| Stage IIIA | T3b | N0 | M0 | No cancer-directed surgery and no radiation | laUC |
| T4a | N0 | M0 | No cancer-directed surgery and no radiation | laUC | |
| T1-T4a | N1 | M0 | No cancer-directed surgery and no radiation | laUC | |
| Stage IIIB | T1-T4a | N2 | M0 | No cancer-directed surgery and no radiation | laUC |
| T1-T4a | N3 | M0 | No cancer-directed surgery and no radiation | mUC | |
| Stage IVA | T4b | Any N | M0 | No cancer-directed surgery and no radiation | laUC |
| Any T | Any N | M1a | No constraint | mUC | |
| Stage IVB | Any T | Any N | M1b | No constraint | mUC |
NOTE. Cancer stage was determined using the TNM classification system.6 la/mUC or MIBC status were determined based on treatment received after diagnosis.
Abbreviations: la/mUC, locally advanced/metastatic urothelial carcinoma; laUC, locally advanced urothelial carcinoma; M, metastasis; MIBC, muscle-invasive bladder cancer; mUC, metastatic urothelial carcinoma; N, node; NMIBC, non–muscle-invasive bladder cancer; T, tumor; Ta, noninvasive papillary; Tis, carcinoma in situ.