Table 3.
Standardized incidence ratios of gastric cancer in patients with Lynch syndrome compared with the KPNC general population
| Variable | No. of observed cases | No. of expected cases | SIR | 95% CI |
| Total | 11 | 1.37 | 8.06 | 4.02–14.42 |
| Sex | ||||
| Female | 4 | 0.69 | 5.77 | 1.57–14.76 |
| Male | 7 | 0.67 | 10.43 | 4.19–21.48 |
| Race and ethnicity | ||||
| Racial and ethnic minoritiesa | 5 | 0.44 | 11.37 | 3.69–26.54 |
| Non-Hispanic White | 6 | 0.93 | 6.48 | 2.38–14.11 |
| MMR gene | ||||
| MLH1 | 2 | 0.26 | 7.74 | 0.94–27.96 |
| MSH2 | 8 | 0.34 | 23.50 | 10.15–46.31 |
| MSH6 | 0 | 0.33 | 0 | 0.00–9.05 |
| PMS2 | 1 | 0.44 | 2.30 | 0.06–12.79 |
CI, confidence interval; KPNC, Kaiser Permanente Northern California; MMR, mismatch repair; SIR, standardized incidence ratio.
a
Included people who were Asian, Black, or Hispanic.