Table 4.
Standardized incidence ratios of small intestinal cancer in patients with Lynch syndrome compared with the KPNC general population
| Variable | No. of observed cases | No. of expected cases | SIR | 95% CI |
| All | 11 | 0.46 | 23.95 | 11.95–42.85 |
| Sex | ||||
| Female | 2 | 0.27 | 7.43 | 0.90–26.85 |
| Male | 9 | 0.19 | 47.30 | 21.63–89.79 |
| Race and ethnicity | ||||
| Racial and ethnic minoritiesa | 3 | 0.15 | 19.62 | 4.05–57.33 |
| Non-Hispanic White | 8 | 0.31 | 26.11 | 11.27–51.44 |
| MMR gene | ||||
| MLH1 | 3 | 0.09 | 34.93 | 7.20–102.08 |
| MSH2 | 6 | 0.11 | 53.45 | 19.62–116.34 |
| MSH6 | 1 | 0.11 | 8.84 | 0.22–49.24 |
| PMS2 | 1 | 0.15 | 6.75 | 0.17–37.63 |
CI, confidence interval; KPNC, Kaiser Permanente Northern California; MMR, mismatch repair; SIR, standardized incidence ratio.
a
Included people who were Asian, Black, or Hispanic.