Table 1.

Study scheme

	Screening	Eradication treatment		Posteradication treatment	Follow-up
		14 d		14 d	28 d
	Visit 1 (day −8 –[-1])	Visit 2 (day 0)	Visit 3 (day 14)		Visit 4 (day 56 ± 3)
Postbiotic/Placebo taking
Eradication treatment
Demographics	+
Medical history	+
Complete blood count	+		+
Serum chemistry	+		+
Anti-HIV Ab, RPR, HBsAg, HCV-Ab	+
Gastroscopy	+
С-13 urease breath test for Helicobacter pylori	+				+
Pregnancy test	+
Signing informed consent	+
Checking inclusion and exclusion criteria		+	+		+
Randomization		+
Initiation of eradication therapy for 14 d + postbiotic/placebo for 28 d		+
7 × 7 Questionnaire		+	+		+
GSRS questionnaire		+	+		+
SF-36 questionnaire		+	+		+
Assessment of adverse effects			+		+
Compliance assessment			+

GSRS, Gastrointestinal Symptom Rating Scale; RPR, rapid plasma reagin.