FIG. 10.

Effect of iNOS inhibitors on TNF-α-induced LTR-driven transcription. Jurkat cells were transfected with LTR-luc. After transfection, cells were stimulated with TNF-α (200 U/ml) in the presence or absence of l-NIL (100 or 300 μM), l-NMMA (100 or 200 μM) or d-NMMA (200 μM), and 5 h later luciferase activity in relative light units (RLU) was determined. Results are the means ± SD of two independent experiments. There are statistically significant differences with respect to the TNF-α alone: l-NIL 100 (P < 0.05), l-NIL 300 (P < 0.01), l-NMMA-100 (P < 0.05), and l-NMMA-200 (P < 0.01).