Table 3.
Sensitivity, specificity, positive and negative predictive values of Select-3, Select-6, oligoclonal bands, or combinations, for diagnosis of multiple sclerosis.
| Sensitivity | Specificity | PPV | NPV | |
|---|---|---|---|---|
| Diagnosis of multiple sclerosis at initial assessment | ||||
| OCB | 0.75 (0.53, 0.90) | 0.76 (0.56, 0.90) | 0.72 (0.51, 0.88) | 0.79 (0.59, 0.92) |
| Select-3 | 0.83 (0.63, 0.95) | 0.48 (0.29, 0.67) | 0.57 (0.39, 0.74) | 0.78 (0.52, 0.94) |
| Select-6 | 0.71 (0.49, 0.87) | 0.86 (0.68, 0.96) | 0.81 (0.58, 0.95) | 0.78 (0.60, 0.91) |
| Select-3 + OCB | 0.67 (0.45, 0.84) | 0.86 (0.68, 0.96) | 0.80 (0.56, 0.94) | 0.76 (0.58, 0.89) |
| Select-6 + OCB | 0.62 (0.41, 0.81) | 0.93 (0.77, 0.99) | 0.88 (0.64, 0.99) | 0.75 (0.58, 0.88) |
| Select-6 + MRI DIS | 0.71 (0.49, 0.87) | 0.90 (0.73, 0.98) | 0.85 (0.62, 0.97) | 0.79 (0.61, 0.91) |
| OCB + MRI DIS | 0.71 (0.49, 0.87) | 0.83 (0.64, 0.94) | 0.77 (0.55, 0.92) | 0.77 (0.59, 0.90) |
| p-values | ||||
| OCB vs Select-3 | 0.157 | 0.005 | 0.015 | 0.890 |
| OCB vs Select-6 | 0.317 | 0.083 | 0.117 | 0.876 |
| Select-3 vs Select-6 | 0.083 | 0.001 | 0.003 | 0.957 |
| Select-3 + OCB vs Select-3 | 0.046 | 0.001 | 0.004 | 0.765 |
| Select-6 + OCB vs Select-6 | 0.157 | 0.157 | 0.232 | 0.337 |
| Select-3 + OCB vs Select-6 + OCB | 0.317 | 0.157 | 0.191 | 0.750 |
| Select-6 + MRI DIS vs OCB + MRI DIS | - | 0.157 | 0.141 | 0.189 |
| Diagnosis of multiple sclerosis at 12-month follow-up | ||||
| OCB | 0.78 (0.58, 0.91) | 0.85 (0.65, 0.96) | 0.84 (0.64, 0.95) | 0.79 (0.59, 0.92) |
| Select-3 | 0.81 (0.62, 0.94) | 0.50 (0.30, 0.70) | 0.63 (0.45, 0.79) | 0.72 (0.47, 0.90) |
| Select-6 | 0.74 (0.54, 0.89) | 0.96 (0.80, 1.00) | 0.95 (0.76, 1.00) | 0.78 (0.60, 0.91) |
| Select-3 + OCB | 0.67 (0.46, 0.83) | 0.92 (0.75, 0.99) | 0.90 (0.68, 0.99) | 0.73 (0.54, 0.87) |
| Select-6 + OCB | 0.63 (0.42, 0.81) | 1.00 (0.87, 1.00) | 1.00 (0.80, 1.00) | 0.72 (0.55, 0.86) |
| Select-6 + MRI DIS | 0.70 (0.50, 0.86) | 0.96 (0.80, 1.00) | 0.95 (0.75, 1.00) | 0.76 (0.58, 0.89) |
| OCB + MRI DIS | 0.74 (0.54, 0.89) | 0.92 (0.75, 0.99) | 0.91 (0.71, 0.99) | 0.77 (0.59, 0.90) |
| p-values | ||||
| OCB vs Select-3 | 0.317 | 0.003 | 0.004 | 0.271 |
| OCB vs Select-6 | 0.317 | 0.083 | 0.090 | 0.877 |
| Select-3 vs Select-6 | 0.157 | 0.001 | 0.001 | 0.377 |
| Select-3 + OCB vs Select-3 | 0.046 | 0.001 | 0.002 | 0.943 |
| Select-6 + OCB vs Select-6 | 0.083 | 0.317 | 0.317 | 0.124 |
| Select-3 + OCB vs Select-6 + OCB | 0.317 | 0.157 | 0.157 | 0.831 |
| Select-6 + MRI DIS vs OCB + MRI DIS | 0.317 | 0.317 | 0.337 | 0.501 |
Abbreviations: MRI DIS – dissemination in space on magnetic resonance imaging (according to McDonald 2017 criteria); NPV – negative predictive value; OCB – serum-unmatched oligoclonal bands in cerebrospinal fluid; PPV – positive predictive value. Estimates provided as proportions with 95% confidence intervals.