Table 2.
Ranking of adhesin protein according to vaccine potential using VaxiJen and their corresponding number of epitopes listed on The Immune Epitope Database (IEDB)
| Rank | Adhesin Protein | Accession No. | Probability of Antigen (VaxiJen) | No. of epitopes (IEDB) |
|---|---|---|---|---|
| 1 | Wag22_ PE_PGRS | Rv1759c | 2,0053 | No data |
| 2 | PE-PGRS33 | Rv1818c | 1,6972 | No data |
| 3 | 19 kDa Antigen | Rv3763 | 1,15 | 14 |
| 4 | mtp | Rv3312A | 0,7609 | No data |
| 5 | PstS-1 | Rv0934 | 0,7312 | 48 |
| 6 | DnaK/Hsp70 | Rv0350 | 0,6417 | 69 |
| 7 | N-acetylmuromoyl-L-alanine amidase | Rv3717 | 0,6327 | No data |
| 8 | HupB | Rv2986c | 0,6089 | No data |
| 9 | HBHA | Rv0475 | 0,5986 | 3 |
| 10 | Type IV pili | Rv3655c | 0,5914 | No data |
| 11 | Membrane protein | Rv2599 | 0,5883 | – |
| 12 | Ag85B | Rv1886c | 0,5842 | – |
| 13 | Type IV pili | Rv3654c | 0,5748 | – |
| 14 | MCE1A | Rv0169 | 0,5666 | – |
| 15 | Protein Kinase D | Rv0931c | 0,5634 | – |
| 16 | ESAT-6 | Rv3875 | 0,5577 | – |
| 17 | Cpn60,2 | Rv0440 | 0,5421 | – |
| 18 | Ag85A | Rv3804c | 0,5259 | – |
| 19 | Apa | Rv1860 | 0,5233 | – |
| 20 | GlnA1 | Rv2220 | 0,5087 | – |
| 21 | L,D Transpeptidase | Rv0309 | 0,5044 | – |
| 22 | Ag85C | Rv0129c | 0,4795 | – |
| 23 | MPT51/Ag85C | Rv3803c | 0,4515 | – |
| 24 | GAPDH | Rv1436 | 0,4123 | – |
| 25 | Type IV pili | Rv3656c | 0,3738 | – |
| 26 | Malate Synthase | Rv1837c | 0,3676 | – |
N.B: (-)Denotes that this adhesin protein was not investigated for this study and therefore data (if available) was not obtained.