TABLE 4.
Subgroup analysis of LDH.
| Subgroup | No.of studies | SMD | 95%CI | p-Value between subgroups | Heterogeneity within subgroups | |
|---|---|---|---|---|---|---|
| I2 (%) | p-Value | |||||
| Model | 0.01 | |||||
| Block LAD | 9 | −4.75 | −8.13, −1.37 | 87% | <0.01 | |
| Ligation and reperfusion | 6 | −5.37 | −8.59, −2.15 | 92% | <0.01 | |
| ISO | 4 | −1.45 | −2.04, −0.87 | 0% | 0.71 | |
| Dosage | 0.01 | |||||
| ≤20 mg/kg | 8 | −1.41 | −1.84, −0.98 | 35% | 0.15 | |
| 21–50 mg/kg | 5 | −4.76 | −9.01, −0.51 | 88% | <0.01 | |
| >50 mg/kg | 6 | −7.19 | −11.48, −2.90 | 92% | <0.01 | |
| Administration method | 0.69 | |||||
| Intravenous injection | 7 | −5.1 | −9.07, −1.13 | 89% | <0.01 | |
| gavage | 2 | −5.2 | −12.56, 2.17 | 95% | <0.01 | |
| intraperitoneal injection | 10 | −3.38 | −5.35, −1.36 | 86% | <0.01 | |
| Administration time | 0.22 | |||||
| before modeling | 10 | −2.83 | −4.22, −1.45 | 83% | <0.01 | |
| after modeling | 7 | −5.21 | −9.78, −0.65 | 89% | <0.01 | |
| other times | 2 | −7.93 | −14.47, −1.39 | 88% | <0.01 | |
| Species | 0.06 | |||||
| SD rats | 16 | −4.68 | −6.84, −2.52 | 89% | <0.01 | |
| ICR mice | 1 | −2.27 | −4.04, −0.51 | - | - | |
| Wistar rats | 1 | −1.60 | −2.54, −0.66 | - | - | |
| 4-way ovoss | 1 | −1.36 | −2.81, 0.09 | - | - | |