Fig 2.

Schematic structure of the E2F family of transcription factors. All member of the E2F subgroup contain a DNA-binding domain (DNA). E2F1 through –6 contain a leucine-zipper dimerization domain that mediates interactions with DP proteins (DP), and E2F1 through 3 also have a cyclin A-binding region (CycA). C-terminal transactivation domains that mediate binding of E2F1 through –5 to pRb family proteins are also indicated. E2F7 has two DNA-binding domains and lacks DP- and pRb-binding regions. DP proteins only have DNA and E2F-binding domains.