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. 2024 Aug 21;6(9):1791–1806. doi: 10.1038/s42255-024-01114-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 6 — a, Glycaemia before and 2 weeks after S961 treatment on Ctrl (n = 10), Ctrl + S961 (n = 9), DT (n = 9) and DT + S961 (n = 10). Right panel: AUC of glycaemia. P values: Ctrl vs DT, ***P = 0.001; Ctrl vs Ctrl + S961, ****P < 0.0001; DT vs DT + S961, ****P < 0.0001; Ctrl + S961 vs DT + S961, P = 0.1903. b, Plasma insulin release under random-fed conditions in Ctrl (gray, n = 10), Ctrl + S961 (black, n = 9), DT (pink, n = 9) and DT + S961 (red, n = 9). P values: Ctrl vs DT, **P = 0.0015; Ctrl vs Ctrl + S961, ****P < 0.0001; DT vs DT + S961, ***P = 0.0002; Ctrl + S961 vs DT + S961, P = 0.9182. c, Immunofluorescence on pancreatic sections from Ctrl or DT-treated β-only mice with or without S961 treatment. INS, green; Ki67, gray; DAPI, blue. Scale bars, 20 µm. d, Percentage of double-positive INS⁺KI67⁺ in INS⁺ population in Ctrl (n = 4), Ctrl + S961 (n = 4), DT (n = 4) and DT + S961 (n = 4). P values: Ctrl vs DT, P = 0.6857; Ctrl vs Ctrl + S961, *P = 0.286; DT vs DT + S961, *P = 0.286; Ctrl + S961 vs DT + S961, *P = 0.286. Only male mice were used. All data are shown as mean ± s.e.m. P values are from two-tailed Mann–Whitney tests.

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