Fig. 4.

PAR4 deletion improves glucose tolerance in high fat diet-fed mice. a Fasting blood glucose measured in tail-vein blood of wildtype (WT) mice fed chow or HFD and PAR4^-/- littermate mice fed HFD for 6 weeks. b Blood glucose time-course after oral glucose challenge in the three groups of mice after 6 weeks of dietary intervention. c Area under the curve (AUC) of the oral glucose tolerance test (GTT) timecourse. d Transcript expression of the metabolic regulator genes encoding lipprotein lipase (Lipe), adipocyte triglyceride lipase (ATGL, Pnpla2) and perilipin (Plin1) in visceral WAT in the three groups after 8 weeks dietary intervention. e Lipase activity assay performed in fresh WAT from the three groups of mice after 8 weeks. Data show mean ± SD, *denotes P<0.05