Table 1.
Clinicopathologic features of females with HR+HER2- non-metastatic invasive breast cancer and 1–3 positive sentinel lymph nodes undergoing upfront surgery.
| Overall | No high-risk features | ≥1 high-risk features | p | ||
|---|---|---|---|---|---|
| n | 12,891 | 6,519 | 6,372 | ||
| Age (years) | 59.3 ± 12.6 | 60.3 ± 11.8 | 58.4 ± 13.2 | <0.001 | |
| Race/Ethnicity | |||||
| White | 10709 (83.1) | 5543 (85.0) | 5166 (81.1) | ||
| Black | 1266 (9.8) | 524 (8.0) | 742 (11.6) | <0.001 | |
| Asian | 545 (4.2) | 257 (3.9) | 288 (4.5) | ||
| Other/Unknown | 371 (2.9) | 195 (3.0) | 176 (2.8) | ||
| Charlson/Deyo Score | |||||
| 0 | 10699 (83.0) | 5414 (83.0) | 5285 (82.9) | ||
| 1 | 1557 (12.1) | 782 (12.0) | 775 (12.2) | 0.98 | |
| 2 | 377 (2.9) | 190 (2.9) | 187 (2.9) | ||
| ≥3 | 258 (2.0) | 133 (2.0) | 125 (2.0) | ||
| Insurance Status | |||||
| Not Insured | 225 (1.7) | 126 (1.9) | 99 (1.6) | ||
| Private Insurance | 6931 (53.8) | 3399 (52.1) | 3532 (55.4) | ||
| Medicaid | 915 (7.1) | 441 (6.8) | 474 (7.4) | <0.001 | |
| Medicare | 4549 (35.3) | 2424 (37.2) | 2125 (33.3) | ||
| Other Government | 176 (1.4) | 79 (1.2) | 97 (1.5) | ||
| Unknown | 95 (0.7) | 50 (0.8) | 45 (0.7) | ||
| Institution Type | |||||
| Community Cancer Center | 951 (7.4) | 512 (7.9) | 439 (6.9) | ||
| Comprehensive Community Cancer Program | 5340 (41.4) | 2711 (41.6) | 2629 (41.3) | ||
| Academic/Research Program | 3288 (25.5) | 1716 (26.3) | 1572 (24.7) | <0.001 | |
| Integrated Network Cancer Program | 2594 (20.1) | 1342 (20.6) | 1252 (19.6) | ||
| Unknown | 718 | 238 | 480 | ||
| Pathologic Tumor Size (mm) | 25.6 ± 25.3 | 19.8 ± 9.5 | 31.5 ± 33.7 | <0.001 | |
| Pathologic Tumor Stage | |||||
| T1 | 6274 (48.6) | 3887 (59.6) | 2387 (37.4) | <0.001 | |
| T2 | 5577 (43.3) | 2589 (39.7) | 2988 (46.9) | ||
| T3 | 954 (7.4) | 16 (0.2) | 938 (14.7) | ||
| T4 | 86 (0.7) | 27 (0.4) | 59 (0.9) | ||
| Tumor Grade | |||||
| 1 | 2414 (18.7) | 1945 (29.8) | 469 (7.4) | <0.001 | |
| 2 | 7748 (60.1) | 4574 (70.2) | 3174 (49.8) | ||
| 3 | 2729 (21.2) | 0 (0.0) | 2729 (42.8) | ||
| Ki-67 | |||||
| <20% | 7685 (59.6) | 6519 (100.0) | 1166 (18.3) | <0.001 | |
| ≥20% | 5206 (40.4) | 0 (0.0) | 5206 (81.7) | ||
| Lymphovascular Invasion | |||||
| Absent | 6908 (53.6) | 3988 (61.2) | 2920 (45.8) | <0.001 | |
| Present | 4676 (36.3) | 1843 (28.3) | 2833 (44.5) | ||
| Unknown | 1307 (10.1) | 688 (10.6) | 619 (9.7) | ||
| Estrogen Receptor | |||||
| Negative | * | * | * | <0.001 | |
| Positive | 12834 (99.6) | 6514 (99.9) | 6320 (99.2) | ||
| Unknown | * | * | * | ||
| Progesterone Receptor | |||||
| Positive | 11816 (91.7) | 6121 (93.9) | 5695 (89.4) | <0.001 | |
| Negative/Unknown | 1075 (8.3) | 398 (6.1) | 677 (10.6) | ||
| Breast Surgery | |||||
| Partial Mastectomy | 7256 (56.3) | 4046 (62.1) | 3210 (50.4) | <0.001 | |
| Mastectomy | 5635 (43.7) | 2473 (37.9) | 3162 (49.6) | ||
| Axillary surgery | |||||
| SLNB alone | 8963 (69.5) | 4757 (73.0) | 4206 (66.0) | <0.001 | |
| SNLB then ALND | 3928 (30.5) | 1762 (27.0) | 2166 (34.0) | ||
| Number of SLN removed | 3.2 ± 2.7 | 3.0 ± 2.6 | 3.3 ± 2.8 | <0.001 | |
| Number of positive SLN | 1.3 ± 0.6 | 1.3 ± 0.5 | 1.4 ± 0.6 | <0.001 | |
| Number of total LN removed | 6.1 ± 6.4 | 5.6 ± 6.1 | 6.6 ± 6.7 | <0.001 | |
| Number of total positive LN | 1.8 ± 2.2 | 1.6 ± 1.7 | 2.0 ± 2.5 | <0.001 | |
Abbreviations: SLNB: sentinel lymphadenectomy; ALND: axillary lymph node dissection; SLN: sentinel lymph nodes; LN: total lymph nodes
*
Results suppressed: NCDB does not permit aggregate results for cell sizes < 10
Note: Table cells show frequency (column percent) or mean ± standard deviation.