Table 2.
Clinicopathologic features of females with HR+HER2- non-metastatic invasive breast cancer and 1–3 positive sentinel lymph nodes without high-risk features who underwent upfront surgery and completion axillary lymph node dissection.
| Overall | Number of positive sentinel lymph nodes | p | ||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | ||||
| n | 1,762 | 1,159 | 419 | 184 | ||
| Pathologic Tumor Size (mm) | 22.0 ± 10.2 | 21.2 ± 10.0 | 23.2 ± 10.2 | 24.3 ± 11.0 | <0.001 | |
| Pathologic Tumor Stage | ||||||
| T1 | 857 (48.6) | 603 (52.0) | 180 (43.0) | 74 (40.2) | 0.001 | |
| T2 | 883 (50.1) | 544 (46.9) | 235 (56.1) | 104 (56.5) | ||
| T3/4 | 22 (1.2) | * | * | * | ||
| Tumor Grade | ||||||
| 1 | 430 (24.4) | 293 (25.3) | 94 (22.4) | 43 (23.4) | 0.48 | |
| 2 | 1332 (75.6) | 866 (74.7) | 325 (77.6) | 141 (76.6) | ||
| Lymphovascular Invasion | ||||||
| Absent | 983 (55.8) | 680 (58.7) | 218 (52.0) | 85 (46.2) | <0.001 | |
| Present | 591 (33.5) | 354 (30.5) | 153 (36.5) | 84 (45.7) | ||
| Unknown | 188 (10.7) | 125 (10.8) | 48 (11.5) | 15 (8.2) | ||
| Estrogen Receptor | ||||||
| Positive | 1,760 (99.9) | * | * | * | 0.06 | |
| Negative/Unknown | 1 (0.1) | * | * | * | ||
| Progesterone Receptor | ||||||
| Positive | 1,647 (93.5) | 1075 (92.8) | 399 (95.2) | 173 (94.0) | 0.20 | |
| Negative/Unknown | 115 (6.5) | 84 (7.2) | 20 (4.8) | 11 (6.0) | ||
| Breast Surgery | ||||||
| Partial Mastectomy | 623 (35.4) | 407 (35.1) | 146 (34.8) | 70 (38.0) | 0.72 | |
| Mastectomy | 1,139 (64.6) | 752 (64.9) | 273 (65.2) | 114 (62.0) | ||
| Number of SLN removed | 3.3 ± 3.4 | 2.8 ± 3.0 | 4.0 ± 3.9 | 4.9 ± 3.2 | <0.001 | |
| Number of total LN removed | 12.3 ± 7.6 | 11.3 ± 7.3 | 13.6 ± 7.8 | 15.8 ± 10.0 | <0.001 | |
| Number of total positive LN | 2.6 ± 3.0 | 1.9 ± 2.4 | 3.4 ± 3.1 | 5.3 ± 3.8 | <0.001 | |
Abbreviations: SLN: sentinel lymph nodes; LN: total lymph nodes
*
Results suppressed: NCDB does not permit aggregate results for cell sizes < 10
Note: Table cells show frequency (column percent) or mean ± standard deviation. No differences were seen when comparing demographic information between the cohorts, and are therefore not shown.