FIG. 5.

Requirement of the cadherin-catenin system for efficient entry and cell-cell spread of HSV-1. L and EL cells were incubated at 37°C for 30 min with 10⁵ PFU of HSV-1(KOS)tk/well. At 6 h (A) or 2 days (B) after inoculation, the cells were fixed and stained with X-Gal. Upper panel, high magnification; lower panel, low magnification; bars, 200 μm. These results are representative of three independent experiments.