Skip to main content
. 2024 Jul 8;11(36):2403262. doi: 10.1002/advs.202403262

Figure 2.

Figure 2

Knockdown of DCAF7 increases the chemosensitivity and suppresses the metastasis of NPC cells in vivo. A) Representative images displaying xenografts in nude mice. B,C) Growth curves and weights of xenograft tumors subjected to the indicated treatments. Mean (n = 8) ± s.d. Two‐way ANOVA in B, Student's t‐test in C, ** p < 0.01, *** p < 0.001. D) Schematic representation of the in vivo lymphatic metastasis model. E) Representative images of H&E‐stained footpad tumors; scale bars = 100 µm. F,G) Representative images and quantitative data for lymph nodes (n = eight mice per group). Mean (n = 8) ± s.d. Student's t‐test, ** p < 0.01. H,I) IHC images of popliteal lymph nodes stained with an anti‐pancytokeratin antibody, along with the corresponding metastasis rates. Scale bars = 500 µm. J,K) Representative images and quantification of macroscopic lung surface metastatic foci. Mean (n = 8) ± s.d. Student's t‐test, ** p < 0.01. L,M) Histological images of H&E‐stained lung tissue sections and quantification of microscopic lung metastatic foci. Scale bars = 1000 µm (left), 500 µm (middle), 100 µm (right). Mean (n = 8) ± s.d. Student's t‐test, *** p < 0.001.