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Schematic representation of NUP98 expression and structure in cells. (A) The expression involves alternative splicing and autoproteolytic cleavage, leading to the production of mature NUP98 and NUP96 proteins, as well as an 8 kD fragment. (B) The structure of the wild‐type NUP98 protein and position of NUP98 fusion breakpoints in leukemia. Arrows indicate exon numbers. GBD, Gle2‐binding domain; NLS, nuclear localization signal.
