Table 2.

Mixed-effects models of plasma Aβ isoforms in APPswe MC vs. NC

	Age	Mut status	Mut status*Age
	Estimate [SE]	Estimate [SE]	Estimate [SE]
Aβ1–38 (pg/mL)	ns	46.5 [2.76]***	ns
Aβ1–40 (pg/mL)	ns	639 [34.4]***	4.95 [1.79]**
Aβ1–42 (pg/mL)	ns	67.9 [3.03]***	0.476 [0.151]**
Aβ1–42/1–40	-519*10^(-4) [184*10^(-4)]**	ns	ns

Mixed-effects models of repeated-measures data in LC-MS/MS analysis. 72 plasma samples were included from APPswe MC (n = 13, 23 samples) and NC (n = 29, 49 samples). Table showing estimates, the standard error (SE) within brackets and statistical significance (*p < 0.05, **p < 0.01, ***p < 0.001). Mut status = Mutation status, here mutation carriers compared to non-carriers. Age was centered to 54 years, the mean age at onset in the APPswe family. All models were corrected for APOE ɛ4 status and sex