Table 2.
Mixed-effects models of plasma Aβ isoforms in APPswe MC vs. NC
Age | Mut status | Mut status*Age | |
---|---|---|---|
Estimate [SE] | Estimate [SE] | Estimate [SE] | |
Aβ1–38 (pg/mL) | ns | 46.5 [2.76]*** | ns |
Aβ1–40 (pg/mL) | ns | 639 [34.4]*** | 4.95 [1.79]** |
Aβ1–42 (pg/mL) | ns | 67.9 [3.03]*** | 0.476 [0.151]** |
Aβ1–42/1–40 | -519*10^(-4) [184*10^(-4)]** | ns | ns |
Mixed-effects models of repeated-measures data in LC-MS/MS analysis. 72 plasma samples were included from APPswe MC (n = 13, 23 samples) and NC (n = 29, 49 samples). Table showing estimates, the standard error (SE) within brackets and statistical significance (*p < 0.05, **p < 0.01, ***p < 0.001). Mut status = Mutation status, here mutation carriers compared to non-carriers. Age was centered to 54 years, the mean age at onset in the APPswe family. All models were corrected for APOE ɛ4 status and sex