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. 2024 Sep 25;16:207. doi: 10.1186/s13195-024-01574-w

Table 2.

Mixed-effects models of plasma Aβ isoforms in APPswe MC vs. NC

Age Mut status Mut status*Age
Estimate [SE] Estimate [SE] Estimate [SE]
Aβ1–38 (pg/mL) ns 46.5 [2.76]*** ns
Aβ1–40 (pg/mL) ns 639 [34.4]*** 4.95 [1.79]**
Aβ1–42 (pg/mL) ns 67.9 [3.03]*** 0.476 [0.151]**
Aβ1–42/1–40 -519*10^(-4) [184*10^(-4)]** ns ns

Mixed-effects models of repeated-measures data in LC-MS/MS analysis. 72 plasma samples were included from APPswe MC (n = 13, 23 samples) and NC (n = 29, 49 samples). Table showing estimates, the standard error (SE) within brackets and statistical significance (*p < 0.05, **p < 0.01, ***p < 0.001). Mut status = Mutation status, here mutation carriers compared to non-carriers. Age was centered to 54 years, the mean age at onset in the APPswe family. All models were corrected for APOE ɛ4 status and sex