Table 3.

Mixed-effects models of plasma Aβ isoforms in PSEN1 (p.H163Y) MC vs. NC

	Age	Mut status	Mut status*Age
	Estimate [SE]	Estimate [SE]	Estimate [SE]
Aβ1–38 (pg/mL)	0.134 [0.044]**	ns	ns
Aβ1–40 (pg/mL)	1.44[0.434]**	ns	ns
Aβ1–42 (pg/mL)	ns	ns	ns
Aβ1–42/1–40	-507*10^(-4) [188*10^(-4)]**	ns	ns

Mixed-effects models of repeated-measures data in LC-MS/MS analysis. 69 plasma samples were included from PSEN1 (p.H163Y) MC (n = 5, 20 samples) and NC (n = 29, 49 samples). Table showing estimates, the standard error (SE) within brackets and statistical significance (*p < 0.05, **p < 0.01, ***p < 0.001). Mut status = Mutation status, here mutation carriers compared to non-carriers. Age was centered to 52 years, the mean age at onset in the PSEN1 family. All models were corrected for APOE ɛ4 status and sex