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. 2024 Sep 24;25(1):2398801. doi: 10.1080/15384047.2024.2398801

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 2. — CD8HTM and CD28HTM CAR-T products lack exhaustion and possess memory phenotypes. (a) effector, effector memory, central memory, and naïve/stem cell memory-like phenotypes among matched CD8HTM and CD28HTM CAR-T cells produced from n = 3 donors. Representative flow cytometry plots are shown. (b) prevalence of 0 to 4 exhaustion markers expressed among matched CD8HTM and CD28HTM CAR-T cells produced from 3 donors. SPICE plots demonstrating the average number and type of exhaustion marker expression. CD8HTM and CD28HTM memory (a) and exhaustion (b) phenotypes were not statistically different. Statistical analyses used two-way ANOVA adjusted for multiple comparisons. Error bars reflect the standard error of the mean (SEM).