Table 1.

Changes in laboratory values upon anakinra.

Study time	Baseline	Day 7	p	Day 14	p	Day 21	p	Day 28	p	Day 35	p
n	18	18		17		17		17		17
Androstenedione, nmol/L	7.1 [5.8, 8.8]	7.8 [6.3, 10.6]	0.048	7.5 [5.8, 9.4]	0.48	7.1 [6.1, 9.9]	0.71	7.1 [5.9, 9.9]	0.91	7.6 [6.2, 9.6]	0.35
Testosterone, nmol/L	1.4 [1.2, 1.7]	1.5 [1.3, 2.1]	0.04	1.5 [1.2, 1.8]	0.21	1.6 [1.2, 2.0]	0.39	1.4 [1.2, 2.0]	0.41	1.4 [1.1, 1.8]	0.94
CRP, mg/dL	3.3 [1.3, 5]	0.7 [0.5, 1.2]	<0.001	1.2 [0.7, 6.1]	0.13	1.1 [0.7, 2.4]	<0.01	1.1 [0.8, 1.3]	<0.001	3.1 [1.5, 4.5]	0.66
Oestradiol, pmol/L	191 [164, 225]	209 [201, 245]	0.01	208 [195, 301]	0.01	214 [181, 305]	0.01	204 [158, 225]	0.13	194 [158, 225]	0.10
Progesterone, nmol/L	0.27 [0.18, 0.40]	0.19 [0.12, 0.35]	0.30	0.35 [0.20, 0.47]	0.55	0.26 [0.18, 0.43]	0.78	0.35 [0.16, 0.42]	0.51	0.29 [0.20, 0.42]	0.59
FSH, IU/L	5.8 [4.8, 6.3]	6.1 [4.7, 6.9]	0.98	5.7 [5.0, 6.5]	0.74	6.0 [2.9, 6.4]	0.60	5.7 [4.6, 6.4]	0.32	5.4 [4.5, 5.9]	0.18
LH, IU/L	13.8 [11.4, 18.5]	14.1 [10.9, 18.0]	0.85	15.6 [10.5, 20.6]	0.52	14.1 [9.4, 16.8]	0.44	11.8 [9.0, 18.7]	0.62	12.3 [9.4, 18.5]	0.94
AMH, pmol/L	55.2 [49.5, 88.3]	58.3 [49.5, 82.5]	0.12	58.0 [46.3, 72.4]	0.26	62.2 [46.7, 81.2]	0.46	56.6 [44.9, 85.7]	0.04	54.5 [39, 69.5]	0.94
SHBG, nmol/L	27.1 [17.0, 39.6]	29.2 [16.3, 41.6]	0.02	23.4 [16.5, 38.8]	0.96	27.3 [16.2, 43.6]	0.14	24.6 [15.7, 44.2]	0.31

Serum androgens were measured with tandem mass spectrometry (LC-MS/MS). High-sensitivity CRP was measured with an immunoturbidimetric assay (Tina-quant C-Reactive Protein IV; Roche Diagnostics GmbH). AMH, estradiol, FSH, LH, and SHBG were measured with ECLIA (Elecsys AMH Plus, Elecsys Estradiol III, Elecsys FSH, Elecsys LH, and Elecsys SHBG, Roche Diagnostics GmbH).