Table 2.
Absolute and relative change from baseline in androgens and CRP.
| Study day | Day 7 | Day 14 | Day 21 | Day 28 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Treatment | Anakinra | Anakinra | No treatment | Anakinra | Anakinra | No treatment | Anakinra | Anakinra | No treatment | Anakinra | Anakinra | No treatment |
| n | 18 | 7 | 7 | 17 | 7 | 6 | 17 | 7 | 7 | 17 | 7 | 6 |
| Absolute change in androstenedione, nmol/L | 0.5 [−0.1, 1.6] | 0.77 [0.0, 1.9] | 1.3 [0.1, 2.4] | 0.3 [0.0, 1.3] | 0.8 [−0.3, 1.7] | 1.0 [−0.3, 2.7] | 0.5 [−0.1, 1.0] | 0.6 [0.06, 1.0] | 2.9 [−0.9, 3.9] | 0.2 [−1.2, 0.7] | 0.6 [−0.8, 1.7] | 1.8 [−0.8, 7.4] |
| Relative change in androstenedione, % | 7.1 [−1.3, 22.3] | 7.4 [0.7, 22.3] | 9.6 [−0.2, 23.6] | 6.7 [−0.2, 13.9] | 9.1 [−2.6, 16.4] | 8.5 [−4.0, 26.8] | 8.7 [−0.8, 19.0] | 8.7 [0.6, 17.1] | 30.5 [−8.7, 57.4] | 4.3 [−15.8, 9.8] | 7.2 [−9.9, 20.4] | 14.7 [−11.8, 42.7] |
| Absolute change in testosterone, nmol/L | 0.2 [0.0, 0.3] | 0.2 [0.1, 0.3] | 0.3 [0.0, 0.4] | 0.1 [−0.1, 0.1] | −0.1 [−0.2, 0.1] | 0.5 [0.0, 0.8] | 0.1 [0.0, 0.4] | 0.3 [0.05, 0.5] | 0.7 [0.1, 1.1] | 0.1 [−0.1, 0.3] | 0.3 [−0.02, 0.5] | 0.3 [−0.1, 1.2] |
| Relative change in testosterone, % | 11.6 [1.2, 23.3] | 9.7 [4.0, 15.4] | 9.3 [−1.0, 26.2] | 7.9 [−7.9, 17.9] | −4.0 [−8.4, 8.4] | 17.3 [1.0, 61.1] | 10.7 [−0.3, 20.3] | 15.9 [2.7, 17.8] | 40.1 [6.1, 51.8] | 3.9 [−10.0, 22.8] | 22.8 [−1.8, 24.6] | 11.03 [−4.0, 37.1] |
| Absolute change in CRP, mg/L | −1.8 [−4.3, −0.5] | −0.8 [−0.9, −0.3] | −0.3 [−3.5, 0.1] | −0.4 [−3.2, 2.6] | 0.0 [−0.5, 5.0] | −0.2 [−7.1, 0.3] | −0.8 [−4.0, −0.5] | −0.6 [−1.0, −0.3] | −0.2 [−2.2, 0.1] | −0.7 [−3.0, −0.3] | −0.4 [−1.1, −0.3] | −0.2 [−0.7, 0.1] |
| Relative change in CRP, % | −70.4 [−85.9, −35.2] | −34.8 [−61.9, −21.7] | −27.3 [−41.8, 2.1] | −20.0 [−75.0, 37.1] | 0.0 [−26.7, 134.9] | −19.1 [−45.0, 13.8] | −50.0 [−68.9, −17.1] | −25.0 [−52.8, −17.1] | −9.5 [−23.2, 3.8] | −42.9 [−71.4, −25.0] | −42.9 [−48.9, −25.8] | −11.7 [−18.1, 4.9] |
Changes are relative to the baseline value of each parameter. Values are represented as median and interquartile range. Androgens were measured with tandem-mass spectrometry (LC-MS/MS), and CRP was measured with immunoturbidimetric assay (Tina-quant C-Reactive Protein IV; Roche Diagnostics GmbH).
CRP, C-reactive protein.