Table 1. MLEs of demographic and selective parameters in the two-epoch population growth model, obtained by using different functional classes of human SNPs.
Functional class | No. of SNPs | MLEs | LRT statistic (df) | P value |
---|---|---|---|---|
Demography | ||||
Noncoding | 36,337 | 9512.2 (2) | «10-10 | |
Selection | ||||
Nonsynonymous | 880 | 66.14 (1) | «10-10 | |
Synonymous | 892 | 0.238 (1) | 0.890 | |
Noncoding indel | 2,710 | 5.128 (1) | 0.024 |
τ ≡ time back to population size change; ν ≡ ratio of ancestral to current population size (NA/Nc); γ ≡ selection size parameter (2Ncs).