Figure 3.

Involvement of upregulated RTP4 in corneal HSV-1 infection in T2D mice. (A) Quantitative PCR results showed that Rtp4 had a higher expression level in murine corneal epithelium than corneal stroma. (B, C) Representative images of RTP4 staining in control and T2D mice, and healthy donors and patients with T2D (n = 3 per group). (D) Representative pictures of ICP4 and RTP4 staining in control and T2D mice at 5 Dpi (n = 3 per group). (E) Quantitative PCR analysis of Rtp4 gene expression in murine corneas. MOCK, without HSV-1 infection; HSV-1, at 5 Dpi. **P < 0.01, ***P < 0.001.